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目的分析小剂量米非司酮2次疗法对月经周期的调节作用,寻找一种简单、方便、经济、可行、易于被患者接受的月经周期疗法。方法选取2015年10月-2016年7月该院门诊接待的需要调节月经周期的100例女性作为目标对象,采用数字表达法分组,奇数纳入对照组(49例),偶数纳入观察组(51例)。对照组采用月经提前法,肌肉注射黄体酮,每日1次,1次25 mg,连续5日;观察组月经来潮后第25日开始用药,睡前口服米非司酮,25 mg每次,12 h后再次口服5 mg,发放问卷调查表,比较两组患者调节成功率、症状改善情况及不良反应发生情况。结果观察组调节成功率(98.04%)及无痛经率(82.35%)高于对照组(83.67%、63.27%);观察组不良反应发生率为0,低于对照组的8.16%(P<0.05);观察组无效主要原因为漏服1例;观察组用药后第2次月经黄体生成素/卵泡刺激素(LH/FSH)水平与治疗前比较,差异无统计学意义(P>0.05),但低于同期对照组(P<0.05);对照组高于治疗前,观察组痛经VAS水平低于对照组,差异均有统计学意义(P<0.05);观察组连续3次月经周期及痛经持续时间与对照组相比,差异无统计学意义(P>0.05)。结论小剂量米非司酮2次疗法调节月经周期有效率高,可满足患者调节月经的需求,该方法效果肯定,简单、方便、可行,易于被患者接受。
Objective To analyze the effect of low dose mifepristone regimen on the menstrual cycle and to find a simple, convenient, economical and feasible menstrual cycle therapy that is easy to be accepted by patients. Methods A total of 100 women who needed to regulate the menstrual cycle from October 2015 to July 2016 were enrolled in this study. The subjects were divided into two groups according to the number expression method: 49 cases in the odd group and 51 cases in the even group ). In the control group, progesterone was injected intramuscularly once a day for 25 days for 5 consecutive days. In the observation group, menstruation began on the 25th day after menstrual cramps. Mifepristone (25 mg) After 12 h again oral 5 mg, questionnaires were sent to compare the two groups of patients to adjust success rate, symptom improvement and adverse reactions. Results The success rate (98.04%) and painless rate (82.35%) in the observation group were higher than those in the control group (83.67%, 63.27%). The incidence of adverse reactions in the observation group was 0, which was lower than 8.16% in the control group ); The main reason for the observation group was missed by one case; the second menstrual luteinizing hormone / follicle stimulating hormone (LH / FSH) level in the observation group was not significantly different from that before treatment (P> 0.05) But lower than the control group at the same period (P <0.05). The VAS level of the dysmenorrhea in the observation group was lower than that of the control group before treatment (P <0.05), and the observation group had three menstrual cycles and dysmenorrhea There was no significant difference in duration between the two groups (P> 0.05). Conclusions The low dose mifepristone regimen is effective in regulating the menstrual cycle and can meet the needs of patients with menstrual cycle. The method is effective, simple, convenient, feasible and easy to be accepted by patients.