目的 :进一步探讨特殊营养和耐力运动因素对糖尿病实施非药物控制治疗的效果。方法 :本研究以糖尿病大鼠为对象 ,通过 6周耐力训练、硫酸钒盐补充、钒盐补充与运动组合的干预性治疗 ,运用对比分析 ,从血液生化、糖代谢、血乳酸代谢动力学等方面观察了糖尿病代谢紊乱的不同适应性变化。结果 :强化补充钒盐结合耐力训练 6周后 ,糖尿病大鼠空腹血糖降至 6 2 1± 1 4 1mmol/L (P <0 0 5 ) ,胰岛素恢复至 18 16± 2 17U/ml (P <0 0 5 ) ,提示耐力运动结合钒盐补充较大程度地改善了糖尿病大鼠糖和胰岛激素的代谢紊乱。实验中胰岛激素浓度有独立的适应性变化 ,提示钒盐补充在糖尿病治疗中的意义 ,以及结合耐力运动对胰岛细胞和血糖控制的整体干预作用与外周胰岛素敏感性变化的概念可能不同。本研究首次观察到与血糖动力学同步的OGTT血乳酸动力学过程的特点 ,这可能是反映糖尿病治疗和病情发展的新的诊断指标。钒盐补充用于控制糖尿病病程 ,仍需进一步探讨其可能机制。 Objective: To further explore the effect of special nutrition and endurance exercise on non-drug-controlled diabetes mellitus. Methods: In this study, diabetic rats as the object, through 6 weeks of endurance training, vanadium sulfate salt supplementation, vanadium salt supplementation and exercise combination intervention treatment, the use of comparative analysis, from blood biochemistry, glucose metabolism, blood lactate metabolism kinetics In terms of different adaptive changes observed in diabetic metabolic disorders. RESULTS: After 6 weeks of intensive vanadium supplementation with endurance training, the fasting blood glucose in diabetic rats decreased to 62 1 ± 1 41 mmol / L (P 0 05) and insulin to 18 16 ± 2 17 U / ml (P < 0 0 5), suggesting that endurance exercise combined with vanadium salt to a greater extent to improve diabetic rats glucose and pancreatic islet hormones metabolic disorders. The experimental insulinotropin concentration has an independent adaptive changes, suggesting that the significance of vanadium salt in the treatment of diabetes, and endurance exercise on pancreatic islet cells and glycemic control of the overall intervention and changes in peripheral insulin sensitivity concept may be different. This study, for the first time, observes the characteristics of the kinetics of OGTT, which is in synchrony with hyperglycemia, which may be a new diagnostic indicator of the treatment and progression of diabetes mellitus. Vanadium supplementation is used to control the course of diabetes, and its possible mechanism needs to be further explored.