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目的 :探讨高原性心脏病肾小管功能损害情况 ,为保护高原性心脏病肾功能提供实验依据 ;方法 :用酶联免疫法检测 2 2例高原性心脏病患者和 1 0例健康中老年人的尿视黄醇结合蛋白 (RBP)、N -乙酰 -β -D葡萄苷酶 (NAG)水平。同时测定其血尿素氮(BUN)、血肌酐 (Cr) ;结果 :高原性心脏病患者尿RBP、NAG水平较正常对照组显著升高(P <0 .0 1 ) ,而血BUN、Cr无显著差异 (P >0 .0 5 )。其中心功能Ⅲ、Ⅳ级患者较Ⅰ、Ⅱ级患者的RBP、NAG水平有显著差异 (P <0 .0 1 ) ;结论 :高原性心脏病患者存在肾小管功能损害 ,尿RBP、NAG检测是判断其早期肾小管功能损害的敏感指标。动态监测尿RBP、NAG水平变化有助于早期发现其肾小管功能损害情况 ,为指导临床用药、保护高原性心脏病患者肾功能具有一定临床价值
OBJECTIVE: To investigate the renal tubular dysfunction in patients with high altitude heart disease and to provide experimental evidence for the protection of renal function in patients with high altitude heart disease.Methods: Enzyme linked immunosorbent assay was used to detect 22 patients with cardiogenic heart disease and 10 healthy middle-aged and elderly patients Urinary retinol binding protein (RBP), N-acetyl-β-D-glucosidase (NAG) levels. (BUN) and serum creatinine (Cr) were measured at the same time.RESULTS: The urinary RBP and NAG levels in patients with high altitude heart disease were significantly higher than those in normal control group (P <0.01) Significant difference (P> 0.05). The levels of RBP and NAG in patients with grade Ⅲ and Ⅳ functions were significantly different from those in patients with grades Ⅰ and Ⅱ (P <0.01). Conclusion: The renal tubular dysfunction was found in patients with high altitude heart disease and the urinary RBP and NAG levels were To determine the sensitivity of early renal tubular damage. Dynamic monitoring of urine RBP, NAG levels help early detection of renal tubular dysfunction, in order to guide the clinical medication, protection of renal function in patients with high altitude heart disease has some clinical value