Scour depth prediction of offshore pipelines is of great significance to the design and construction of the submarine pipeline projects. In this paper, based on the CFD software package FLUENT and User Defined Function(UDF), an Eulerian two-phase model, which includes an Euler-Euler coupled model for water and sediment phases, and a turbulent model for the fluid phase, is adopted to predict the scour depth around pipelines. The model is verified by observation data obtained from laboratory experiments. On the basis of the simulations, the factors affecting the scour depth, including the effects of incipient velocity, pipe diameter and sediment particle size and so on, were investigated. Meanwhile, according to formulas of incipient velocity of various sediments, approximate calculation on theoretical scour depths is developed for pipelines of seven stations in the South China Sea, where engineering application information is available. Scour depth prediction of offshore pipelines is of great significance to the design and construction of the submarine pipeline projects. In this paper, based on the CFD software package FLUENT and User Defined Function (UDF), an Eulerian two-phase model, which includes an The model is verified by observation data obtained from laboratory experiments. On the basis of the simulations, the factors affecting the scour depth, including the effects of incipient velocity, pipe diameter and sediment particle size and so on, were investigated. Meanwhile, according to formulas of incipient velocity of various sediments, approximate calculation on theoretical sour depths is developed for pipelines of seven stations in the South China Sea, where engineering application information is available.