癌肿的组织发生,是基础生物学与临床实践中的一个重要问题,常被忽视,教科书及专著中亦很少提及。过去,由于受到Cohnheim“胚胎残余”臆说的约束,长久以来总是传统地归结于单个(簇)细胞恶变(“单中心性”起源说)。近三十年,原发性多发性癌发病率渐见增高,且多侵及同一器官或相同的对侧器官,乃由 The occurrence of cancerous tissue is an important issue in basic biology and clinical practice. It is often overlooked and rarely mentioned in textbooks and monographs. In the past, due to the constraints of Cohnheim’s “residue of embryos”, it has long been traditionally attributed to the malignant transformation of single (cluster) cells (“single center” theory of origin). In the past 30 years, the incidence of primary multicancer has gradually increased, and it has invaded the same organ or the same contralateral organ.