Introduction: Current guidelines endorse surveillance colonoscopy at 3 to 5 years following initial detection of neoplasia. However, individual patients‘risks may vary according to age and gender. This study aimed to characterize neoplasia recurrence in a large patient cohort undergoing surveillance colonoscopy. Methods: All patients undergoing two colonoscopies at least 12 months apart between 1996 and 2000, with detection and removal of a polyp on the index colonoscopy, were identified using our endoscopic database to determine the incidence of colo nic neoplasia. Patients were classified according to age (< 50, 50-64, 65-74, ≥75 ears) and gender. Results: Overall, 1803 patients underwent two colonoscopi es at least 12 months apart (median interval, 140 weeks) with removal of a polyp on initial examination. Polyps ≥5 mm were detected in 334 (19%) patients and polyps ≥10 mm in 105 (6%) on subsequent endoscopy. All age and gender groups w ere well matched with respect to size of polyp detected on initial colonoscopy ( P = 0.2). Kaplan-Meier curves and a Cox proportional hazards model demonstrated similar rates of neoplasia recurrence for all patients irrespective of age and gender. Conclusions: Similar rates of neoplasia recurrence were observed among p atients of different gender and age groups on surveillance colonoscopy. From a h ealth resource utilization perspective, these findings support current recommend ations for similar surveillance intervals for patients regardless of age and gen der. Introduction: Current guidelines endorse surveillance colonoscopy at 3 to 5 years following initial detection of neoplasia. However, individual patients’risks may vary according to age and gender. This study aimed to characterize neoplasia recurrence in a large patient cohort under surveillance surveillance. Methods: All patients undergoing two colonoscopies at least 12 months apart between 1996 and 2000, with detection and removal of a polyp on the index colonoscopy, were identified using our endoscopic database to determine the incidence of colo nic neoplasia. Patients were classified according to age (< 50, 50-64, 65-74, ≥75 ears) and gender. Results: Overall, 1803 patients underwent two colonoscopies es at least 12 months apart (median interval, 140 weeks) with removal of a polyp on initial examination. Polyps ≥ 5 mm were detected in 334 (19%) patients and polyps ≥ 10 mm in 105 (6%) on subsequent endoscopy. All age and gender groups w ere well matched with respect to size o f polyp detected on initial colonoscopy (P = 0.2). Kaplan-Meier curves and a Cox proportional hazards model shows similar rates of neoplasia recurrence for all patients irrespective of age and gender. Conclusions: Similar rates of neoplasia recurrence were observed among p atients of From ah ealth resource utilization perspective, these findings support current offers ations for similar surveillance intervals for patients regardless of age and gen der.