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用本实验室建立的 L_(759)及 ZM_(755)两个新瘤株对肿节风及其某些组分进行了药理筛选。结果表明:肿节风干浸膏、肿节风注射液对这两个瘤株均有一定的治疗效应,且在多批实验中瘤重抑制率均在30—60%之间(P<0.001—<0.05);肿节风挥发油也显示出一定的疗效苗头。此外,体外细胞毒试验(台盼兰染色法)也发现,肿节风挥发油对 L615细胞等具有明显的直接杀伤作用;关于肿节风瘤苗的主动免疫效应以及肿节风对机体免疫机能的影响,也在进一步观察之中。
The pharmacological screens for tumour wind and some of its components were performed using two new tumor lines, L_(759) and ZM_(755), established in our laboratory. The results showed that: Tuojie Fenggan extract, Tuojiefeng injection had a certain therapeutic effect on these two tumor strains, and the tumor weight inhibition rate was between 30-60% in multiple batch experiments (P<0.001— <0.05); swollen wind volatile oil also shows a certain therapeutic effect. In addition, in vitro cytotoxicity assay (trypan blue staining method) also found that Stenorrhea volatile oil has obvious direct killing effect on L615 cells, etc.; on the active immune effect of swollen wind tumor vaccine seedlings and swollen wind on the immune function of the body The impact is also being further observed.