采用转糖苷合成了十二烷基葡糖苷。通过正交实验，对原料配比、催化剂用量和醇交换反应温度等因素对产率的影响进行了考查。得到最佳反应条件为 ｎ（糖）∶ｎ（正丁醇）∶ｎ（正十二醇）∶ｎ（催化剂）＝ １∶６∶８∶０００６，反应温度 １１０℃，影响产率的主要因素为正丁醇配料比和催化剂用量 Dodecyl glucoside was synthesized using transglycoside. Through orthogonal experiment, the effects of factors such as the ratio of raw materials, the amount of catalyst and the temperature of alcohol exchange reaction on the yield were investigated. The optimal reaction conditions were: n (n-butanol): n (n-dodecanol): n (catalyst) = 1:6:8:0006, reaction temperature 110 ℃, The main factors for n-butanol ingredients and catalyst dosage