近十多年来龋病的免疫学研究虽不能说是进展迅速,却也对防龋的免疫学机理进行了大量深入的研究,累积了不少资料,找到了一些重要线索。但是免疫制龋至今仍未取得突破,实验研究离临床应用还有一段距离。现就以下几个问题综述国外近年来的研究进展。变形链球菌现已公认变形链球菌S.mutans(以下简称变链)是人、灵长类、啮齿类的主要致龋菌。许多研究均采用灭活变链作为免疫原免疫动物以期产生特异性抗变链抗体,通过抗体来消灭或减少口腔内致龋菌的数量以达到防龋的目的。最近有学者报导志愿者口服变链死菌胶囊,在外分泌液中测得特异性抗体,但未作龋蚀对照。 Although the progress of immunological research on dental caries in the last ten years or so can not be said to be rapid, a great deal of in-depth research has been conducted on the immunological mechanism of dental caries. A lot of information has been accumulated and some important clues have been found. However, there is still no breakthrough in immune caries, and experimental studies are still far from clinical application. The following several issues are summarized in recent years, foreign research progress. Streptococcus mutans is now recognized S. mutans Streptococcus mutans (hereinafter referred to as variable chain) is human, primates, rodents are the major cariogenic bacteria. Many studies have used inactivated variant chains as immunogens to immunize animals in order to produce specific anti-chain variable antibodies, which can eliminate or reduce the number of cariogenic bacteria in the oral cavity to achieve the purpose of caries prevention. Recently, some scholars reported that volunteers oral changru capsule, measured in the exocrine fluid specific antibodies, but not for caries control.