双相真菌马尔尼菲青霉(Penicillium marneffei,PM)感染所致的马尔尼菲青霉病(Penicilliosis marneffei,PSM)是导致我国南方,尤其是广西、广东地区艾滋病患者死亡的主要感染因素[1,2]。PM可致全身多器官侵袭感染,如得不到正确治疗病死率高。然而,目前对PSM抗真菌药物的选择仍主要依靠临床经验,缺乏体外药敏结果的支持,其重要原因与尚未建立标准的 Penicilliosis marneffei (PSM) caused by biphasic fungi Penicillium marneffei (PM) infection is the main cause of death of AIDS patients in southern China, especially in Guangxi and Guangdong [1 ,2]. PM can cause systemic multiple organ infections, such as not correct treatment of high mortality. However, the current choice of PSM antifungal agents is still mainly based on clinical experience, the lack of support for in vitro susceptibility results, the important reason for not having established a standard