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目的了解最近十年广东地区丙型肝炎病毒(HCV)感染途径的特点。方法 采用回顾性调查与前瞻性研究相结合的方法,进行定群随访观察。结果 感染途径明确者占34.5%(38/110),包括静脉吸毒15.5%(17/110),输血及血制品14.5%(16/110)和血液透析4.5%(5/110);感染途径不明确,存在可疑感染因素者占30%(33/110),包括家庭内传播3.6%(4/110),小手术及注射史12.7%(14/110),皮肤损伤性美容10.9%(12/110),职业暴露2.7%(3/110);不明感染途径者占35.4%(39/110)。各组之间年龄大小差异无统计学意义(P>0.05),静脉吸毒均为男性,职业暴露均为女性,与其他组比较,P<0.001。结论 在广东地区,近十年HCV感染的多种途径并存,小手术及注射、皮肤损伤性美容正在成为与静脉吸毒、输血及血制品同等重要的感染途径。不明感染途径者无论数量还是比例都排第一位,是今后预防的主要问题。
Objective To understand the characteristics of hepatitis C virus (HCV) infection in Guangdong in the recent decade. Methods A retrospective survey and prospective study were combined to observe the subgroup. (34/150), including 15.5% (17/110) of intravenous drug use, 14.5% (16/110) of transfusions and blood products, and 4.5% (5/110) of hemodialysis patients. The route of infection was not Clearly, there were 30% (33/110) suspected dominating infections, including 3.6% (4/110) in the family, 12.7% (14/110) in the minor surgery and injection history, 10.9% 110), occupational exposure 2.7% (3/110), and unidentified infection (35.4%) (39/110). There was no significant difference in age between the groups (P> 0.05). Intravenous drug use was male and occupational exposure was female, P <0.001 compared with other groups. Conclusions In Guangdong, many ways of HCV infection coexist in recent ten years. Small surgery and injection and skin damage cosmetic are becoming the same important infection route as intravenous drug use, blood transfusion and blood products. The number of unidentified routes of infection, both in number and proportion, ranks first and is the major issue for prevention in the future.