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目的:探讨不同麻醉方式对肺癌患者术后血清中血管紧张素Ⅱ(Ang-Ⅱ)、血清皮质醇(Cor)、肾上腺素(AD)以及丙二醛(MDA)等应激因子指标水平的影响。方法:选择2014年9月至2015年9月韶关市第一人民医院收治的60例肺癌患者,随机数表法分成两组各30例。观察组采用全麻复合硬膜外麻醉,对照组应用静脉全麻。在肺癌手术围术期的不同阶段采集患者静脉血液进行生化检验,统计比较患者血清中Ang-Ⅱ、Cor、AD、MDA等应激因子指标水平。结果:观察组患者的Ang-Ⅱ、AD、MDA以及Cor指标水平明显低于对照组患者,差异具有统计学意义(P<0.05)。结论:肺癌切除术患者给予全麻复合硬膜外麻醉具有术后应激水平低、细胞免疫系统影响小、康复迅速等优点。
Objective: To investigate the effect of different anesthesia on the levels of serum angiotensin Ⅱ (Ang), serum cortisol (COR), epinephrine (AD) and malondialdehyde (MDA) in lung cancer patients . Methods: Sixty patients with lung cancer who were admitted to First People’s Hospital of Shaoguan from September 2014 to September 2015 were randomly divided into two groups of 30 patients according to the random number table. The observation group was treated with general anesthesia combined with epidural anesthesia and the control group with intravenous anesthesia. Venous blood was collected for biochemical tests at different stages of perioperative period of lung cancer surgery. The level of Ang-Ⅱ, Cor, AD, MDA and other stress factors were statistically compared. Results: The levels of Ang-Ⅱ, AD, MDA and Cor in the observation group were significantly lower than those in the control group, the difference was statistically significant (P <0.05). Conclusion: General anesthesia combined with epidural anesthesia in patients with lung cancer resection has the advantages of low postoperative stress level, small influence of cellular immune system and rapid recovery.