Objective:To investigate the plasma samples obtained from tumor patients using ~1H nuclear magnetic resonance(NMR) spectroscopy,and find the biochemical foundation of abnormal Savda described in traditional Uyghur medicine.Methods:A total of 170 tumor patients with abnormal Savda syndrome who were confirmed clinically were enrolled in this study,and 50 healthy volunteers were set up as controls.The plasma ~1H NMR spectra were analyzed using the orthogonal projection to latent structure with discriminant analysis(OPLS-DA) method with unit variance scaling.The discriminative significance of the metabolites was determined using the Pearson’s product-moment correlation coefficient.Results:Compared with the healthy controls,the tumor patients with abnormal Savda syndrome had uniformly correlative low levels of leucine, isoleucine,valine,histidine,tyrosine,alanine,glutamine,creatine,inositol,α-glucose,and B -glucose(P<0.05), but had significantly high levels of formate,malonic acid,acetone,acetate,acetoacetate,pyruvate,B -hydroxy butyrate,carnitine and lipidtemns such as very low density lipoprotein,low density lipoprotein and unsaturated lipids(P<0.05).Conclusion:Tumor patients with abnormal Savda syndrome had similar metabolic changes and characteristics,which indicated a similar pathogenetic process and provides some biochemical basis for traditional Uyghur medicine theory. Objective: To investigate the plasma samples obtained from tumor patients using ~ 1H nuclear magnetic resonance (NMR) spectroscopy, and find the biochemical foundation of abnormal Savda described in traditional Uyghur medicine. Methods: A total of 170 tumor patients with abnormal Savda syndrome who were confirmed clinically were enrolled in this study, and 50 healthy volunteers were set up as controls. plasma ~ 1H NMR spectra were analyzed using the orthogonal projection to latent structure with discriminant analysis (OPLS-DA) method with unit variance scaling. discriminative significance of the metabolites was determined using the Pearson’s product-moment correlation coefficient. Results: Compared with the healthy controls, the tumor patients with abnormal Savda syndrome had uniformly correlative low levels of leucine, isoleucine, valine, histidine, tyrosine, alanine, glutamine, creatine , inositol, α-glucose, and B-glucose (P <0.05), but had significantly higher high levels of formate, malonic acid, acetone, acetate, acetoacetate, pyruvate, B -hydroxy butyrate, carnitine and lipidtemns such as very low density lipoprotein, low density lipoprotein and unsaturated lipids (P <0.05) .Conclusion: Tumor patients with abnormal Savda syndrome similar metabolic changes and characteristics, which a similar pathogenetic process and provides some biochemical basis for traditional Uyghur medicine theory.