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本文应用铬粒素Ａ（ＣｇＡ）、胃泌素（ＧＡＳ）、生长抑素（ＳＳ）及５－羟色胺（５－ＨＴ）对１２０例普通型胃癌用免疫组化ＳＰ法标记其神经内分泌细胞。结果表明：四种激素抗体检测，以ＣｇＡ最敏感、阳性率最高为３１．７％；高分化腺癌ＣｇＡ阳性率显著高于低分化和未分化癌（Ｐ＜０．０５），但高分化腺癌ＣｇＡ阳性病例以（＋）为主，未分化癌以（＋＋）为主；而ＳＳ．５ＨＴ的阳性率，高、低分化腺癌均高于未分化癌（Ｐ＞０．０５）。ＣｇＡ及５－ＨＴ阳性病例淋巴结转移率高于阴性病例（Ｐ＜０．０５），ＣｇＡ（＋＋）病例术后生存期明显短于ＣｇＡ（＋）及ＣｇＡ（－）者（Ｐ＜０．０５），ＧＡＳ、５－ＨＴ及ＳＳ阳性与阴性病例术后生存期无显著差异。
In this study, 120 cases of common gastric cancer were labeled with chromogranin A (CgA), gastrin (GAS), somatostatin (SS), and serotonin (5-HT) by immunohistochemical SP method to label their neuroendocrine cells. The results showed that the detection of four hormone antibodies was the most sensitive and the highest positive rate of CgA was 31.7%; the positive rate of CgA in highly differentiated adenocarcinoma was significantly higher than that of poorly differentiated and undifferentiated carcinoma (P<0.05), but the differentiation was highly differentiated. Adenocarcinoma CgA-positive cases were mainly (+), undifferentiated carcinomas were mainly (++), and SS. The positive rate of 5HT, high and poorly differentiated adenocarcinomas were higher than those of undifferentiated carcinomas (P>0.05). The lymph node metastasis rate of CgA and 5-HT positive cases was higher than that of negative cases (P<0.05). The postoperative survival period of CgA(++) cases was significantly shorter than that of CgA(+) and CgA(-) (P<0.05). There was no significant difference in postoperative survival between GAS, 5-HT and SS positive and negative cases.