AIM: To evaluate the efficacy of 6 noninvasive liver fi-brosis models and to identify the most valuable model for the prediction of liver fibrosis stage in chronic hepatitis B (CHB) patients.METHODS: Seventy-eight CHB patients were consecutively enrolled in this study. Liver biopsy was performed and blood serum was obtained at admission.Histological diagnosis was made according to the METAVIR system. Significant fibrosis was defined as stage score ≥ 2, severe fibrosis as stage score ≥ 3.The diagnostic accuracy of 6 noninvasive liver fibrosis models, including serum aspartate aminotransferase (AST) to platelet ratio index (APRI), FIB-4, Forn's in - dex, Fibrometer, Hepascore, and Shanghai Liver Fibrosis Group's index (SLFG), was investigated.RESULTS: The APRI, FIB-4 and Forn's index under re -ceiver operating characteristic curve (AUROC) for significant significant fibrosis were 0.71, 0.75 and 0.79, respectively,with a diagnosis accuracy of 67%, 77% and 80%, respectively,and 0.80, 0.87 and 0.86, respectively, under the AUROC for severe fibrosis. The Hepascore, SLFG,and Fibrometer were 0.80, 0.83 and 0.85, respectively under the AUROC for significant fibrosis ( P < 0.01).The diagnosis accuracy of Hepascore and SLFG was 86% and 88%, respectively. The Hepascore, SLFG, and Fibrometer were 0.95, 0.93, and 0.94, respectively, under the AUROC for severe fibrosis ( P < 0.01).CONCLUSION: The models containing direct serum markers have a better diagnostic value than those not containing direct serum markers.