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目的探讨消瘤丸对小鼠移植性肿瘤的抑制和对环磷酰胺的增效作用。方法给小鼠腋下或腹腔接种肉瘤Ｓ１８０或肝癌Ｈ２２肿瘤细胞。结果消瘤丸（１０ｇ／ｋｇ）对小鼠Ｓ１８０的生长有明显抑制作用（Ｐ＜０．０１），抑瘤率达２４％，并可显著增强环磷酰胺（５ｍｇ／ｋｇ）的抑瘤作用（Ｐ＜０．０５）。但对小鼠肝癌Ｈ２２的生长和腹水型肝癌Ｈ２２小鼠的存活期无明显影响。结论消瘤丸对小鼠移植肉瘤有抑瘤作用，对环磷酰胺有增效作用
Objective To investigate the inhibitory effect of Xiaoliu Pill on mice transplanted tumors and the synergistic effect of cyclophosphamide. Methods The mice were inoculated subcutaneously or intraperitoneally with sarcoma S180 or hepatoma H22 tumor cells. Results Xiaoliu Pill (10g/kg) significantly inhibited the growth of mouse S180 (P<0.01), the tumor inhibition rate was 24%, and significantly enhanced the inhibitory effect of cyclophosphamide (5mg/kg). (P<0.05). However, there was no significant effect on the growth of hepatoma H22 and survival of ascites H22 mice. Conclusion Xiaoliu Pills have antitumor effect on transplanted sarcoma in mice and synergistic effect on cyclophosphamide.