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以抑制小鼠肝组织过氧化脂质生成作用为指标,通过单次灌胃给药的量效关系和时效关系的研究,估算了当归补血汤含药血清和当归补血汤整体给药抑制小鼠肝组织过氧化脂质生成作用的药效动力学参数,从定量的角度对当归补血汤含药血清和当归补血汤整体给药抑制小鼠肝组织过氧化脂质生成的作用进行了比较研究。结果表明,当归补血汤血清药理与整体药效抑制小鼠肝组织过氧化脂质生成作用的K_e、t_(1/2(ke))、K_a、t_(1/2(ka))、t_d、t_p等药效动力学参数均较为接近。当归补血汤血清药理与整体药效在抑制小鼠肝组织过氧化脂质生成作用上的一致性,反映出了血清药理作用与整体药效作用时相过程的良好相关性。
Inhibition of lipid peroxidation in liver tissue of mice was used as an indicator. Through the study of the dose-effect relationship and time-effect relationship of single-dose intragastric administration, it was estimated that Danggui Buxue Decoction serum and Danggui Buxue Decoction inhibited mice as a whole. The pharmacodynamic parameters of lipid peroxidation in liver tissue were compared from the quantitative point of view to the effects of Danggui Buxue Decoction serum and Danggui Buxue Decoction on inhibiting lipid peroxide formation in liver tissue of mice. The results showed that the serum pharmacology and overall efficacy of Danggui Buxue Decoction inhibited the lipid peroxidation of liver tissue in mice. K_e, t_(1/2(ke)), K_a, t_(1/2(ka)), t_d, The pharmacodynamic parameters such as t_p are similar. The consistency of serum pharmacology and overall efficacy of DangGui BuXue Decoction in inhibiting lipid production in liver tissue of mice reflects the good correlation between serum pharmacological effects and overall pharmacodynamic effects.