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目的 探讨慢性胃炎患儿血中胃肠激素的变化及其相互间的关系。方法 应用放射免疫测定法 (RIA)、聚合酶链反应 (PCR)等技术对 2 0例经纤维胃镜和病理证实为慢性胃炎患儿血中胃泌素 (GS)、胃动素 (MTL)质量浓度进行测定 ,并以 30例正常儿童作对照。对慢性胃炎组患儿取空腹胃液行幽门螺杆菌 (HP) -DNA检测。结果 慢性胃炎组血清GS及血浆MTL质量浓度均明显高于正常对照组 (P <0 0 1)。两种胃肠激素质量浓度间无相关关系 (r =0 0 5 2 5 ,P >0 0 5 ) ;GS质量浓度增高与胃液 pH值无相关关系 (r=- 0 0 2 85 ,P >0 0 5 ) ;2 0例慢性胃炎患儿胃液HP -DNA阳性 15例。结论 慢性胃炎患儿某些胃肠激素的分泌异常可能直接或间接参与了慢性胃炎的发病过程。HP感染可能是导致胃肠激素分泌异常的另一重要因素。儿童高胃泌素血症可能是综合因素共同作用的结果。推测GS、MTL在分泌释放过程中不存在协同及拮抗作用
Objective To investigate the changes of blood gastrointestinal hormones in children with chronic gastritis and their relationship with each other. Methods The levels of blood gastrin (GS), motilin (MTL) in 20 children with chronic gastritis confirmed by fiber gastroscopy and pathology were detected by radioimmunoassay (RIA) and polymerase chain reaction (PCR) Concentration were measured, and 30 normal children as a control. Helicobacter pylori (HP) -DNA was detected in children with chronic gastritis by fasting gastric juice. Results The levels of serum GS and plasma MTL in chronic gastritis group were significantly higher than those in normal control group (P <0.01). No correlation was found between the two gut hormones (r = 0 0525, P 0 05). There was no correlation between GS concentration and gastric pH (r = - 0 0 2 85, P 0 0 5); 20 cases of chronic gastritis in children with gastric juice HP-DNA positive in 15 cases. Conclusion Some children with chronic gastritis abnormal secretion of gastrointestinal hormones may be directly or indirectly involved in the pathogenesis of chronic gastritis. HP infection may be another important factor that leads to abnormal secretion of gut hormones. Children with hypergastrinemia may be the result of a combination of factors. Speculated GS, MTL in the process of secretion and release there is no synergistic and antagonistic effect