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目的系统评价右旋佐匹克隆与佐匹克隆治疗失眠症患者的疗效及安全性。方法检索国内外科技期刊数据库,纳入右旋佐匹克隆、佐匹克隆治疗失眠症的随机对照试验,并进行Meta分析。结果共纳入7项研究1 021例患者,治疗2周后,2组睡眠障碍量表(SDRS)减分值比较差异无统计学意义[P=0.57,MD=0.77,95%CI(-1.88~3.41)];2组显效率差异无统计学意义[P=0.76,OR=0.96,95%CI(0.73~1.26)];2组头痛头晕、口干、口苦、恶心呕吐、嗜睡、上腹不适等不良反应发生率差异无统计学意义(P>0.05)。结论右旋佐匹克隆与佐匹克隆治疗失眠症疗效及安全性相似。
Objective To evaluate the efficacy and safety of dextro-zopiclone and zopiclone in the treatment of patients with insomnia. Methods The databases of domestic and foreign sci-tech periodicals were searched and included randomized controlled trials of dextro-zopiclone and zopiclone in the treatment of insomnia. Meta-analysis was performed. Results A total of 1021 patients were enrolled in 7 studies. There was no significant difference in SDRS score between the two groups after 2 weeks of treatment (P = 0.57, MD = 0.77, 95% CI -1.88 ~ 3.41)]. There was no significant difference in the apparent efficiency between the two groups (P = 0.76, OR = 0.96, 95% CI, 0.73-1.26). The headache was dizziness, dry mouth, mouth pain, nausea and vomiting, lethargy, There was no significant difference in the incidence of adverse reactions such as discomfort (P> 0.05). Conclusion The efficacy and safety of dextro-zopiclone and zopiclone in the treatment of insomnia are similar.