绒毛膜上皮癌是一种极度恶性之肿瘤,容易发生转移,而且死亡率极高。Ewinq氏认为真性的绒毛膜上皮癌死亡率可达100％,Novak氏报告74例手术治疗的病例,在6个月以内死亡者达86％,其一年生存率仅为17.5％。目前对治疗绒毛膜上皮癌所采用的方法,仍以手术为主,亦有应用放射,激素如男性和女性素,烴基化合物如氮芥和氧化氮氛等,但其治疗效果仍不能令人满意。自1956及1958年M.C.Li,Hertz氏报告采用一种抗叶酸代谢物如Amet- Choriocarcinoma is an extremely malignant tumor that is prone to metastasis and has a high mortality rate. Ewinq believes 100% of true choriocarcinoma deaths. Novak reported 74 surgically treated patients who died 86% within 6 months and had a one-year survival rate of 17.5%. The current treatment of choriocarcinoma by the method is still mainly surgery, but also the application of radiation, hormones such as men and women, hydrocarbons such as nitrogen mustard and nitric oxide atmosphere, but the treatment effect is still not satisfactory . Since 1956 and 1958 M.C.Li, Hertz reported the use of an antifolate metabolite such as Amet-