卵巢早衰(premature ovarian failure,POF)是指女性在40岁以前发生的自然绝经。一般认为人群POF发生率为1%～3%,闭经患者中2%～10%为卵巢早衰〔1〕。POF发病年龄取决于卵巢中原始卵泡的储备及出生后卵泡闭锁的速度。卵泡储备少及闭锁速 Premature ovarian failure (POF) refers to a woman’s natural menopause that occurs before the age of 40 years. Generally believed that the incidence of POF in the population of 1% to 3%, amenorrhea in patients with 2% to 10% of premature ovarian failure [1]. The onset of POF depends on the reserve of primordial follicles in the ovary and the rate of follicular atresia after birth. Less follicle reserve and lock speed