Vickers indentation test was used to study the effects of mineral composition and microstructure on crack resistance of sintered ore, and the initiation and propagation of cracks in different minerals contained in sintered ore were examined. The results indicate that the microstructure of calcium ferrites is a major factor influencing crack resistance of sintered ore. Finer grain size of calcium ferrite will lead to higher cracking threshold and better crack resistance of sintered ore. The formation of calcium ferrite with fine grain size during sintering process is favorable for crack resistance of sintered ore. Vickers indentation test was used to study the effects of mineral composition and microstructure on crack resistance of sintered ore, and the initiation and propagation of cracks in different minerals contained in sintered ore were examined. The results that that microstructure of calcium ferrites is a major Finer grain size of calcium ferrite will lead to higher cracking threshold and better crack resistance of sintered ore. The formation of calcium ferrite with fine grain size during sintering process is favorable for crack resistance of sintered ore.