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目的研究紫参胶囊对内分泌系统作用。方法切除雌性大鼠卵巢模拟围绝经期综合征,观察紫参胶囊高、中、低剂量组与坤宝丸阳性对照组、模型组、正常组大鼠做对照。结果与正常组比较,模型组大鼠脑组织内的5-羟色胺(5-HT)、多巴胺(DA)、去甲肾上腺素(NE)含量显著下降,差异有统计学意义(P<0.05)。紫参胶囊组较坤宝丸组能够明显提高去卵巢大鼠脑组织内NE、5-HT,差异有统计学意义(P<0.05)。与模型组对照,紫参胶囊高、中、低剂量组可显著提高大鼠血中雌激素含量,差异有统计学意义(P<0.05)。结论紫参胶囊通过调节自主神经、影响下丘脑-腺垂体-卵巢生殖轴来治疗围绝经期综合征。
Objective To study the effect of purple ginseng capsule on endocrine system. Methods Female ovariectomized rats were enrolled in this study. The rats in control group, model group and normal group were treated with high, medium and low doses of ZuShen Capsule and KunPao pills positive control group. Results Compared with the normal group, the contents of 5-HT, DA and NE in the model group were significantly decreased (P <0.05). Zichang capsule group than the kuobao pill group can significantly improve the ovariectomized rat brain NE, 5-HT, the difference was statistically significant (P <0.05). Compared with the model group, the high, medium and low doses of Zishen Capsules significantly increased the estrogen levels in the blood of rats, with statistical significance (P <0.05). Conclusion Zishen Capsule can treat perimenopausal syndrome by regulating the autonomic nerve and affecting the hypothalamic-pituitary-ovarian reproductive axis.