论文部分内容阅读
急性毒性试验:天然麝香以水温浸配成50mg/ml;3-甲基十五环麝香酮(简称麝香酮)用聚氧化乙烯月桂醚作助溶剂,配成20 mg/ml 乳剂。小鼠尾静脉给药按序贯法求 LD_(50),北京及上海麝香酮的 LD_(50)分别为172、152 mg/kg,助溶剂为2500 mg/kg,腹腔给药用简单机率单位法求 LD_(50),北京及上海麝香酮的 LD_(50)分别为270、290mg/kg,助溶剂为3000mg/kg。
Acute toxicity test: Natural musk was immersed into water at a temperature of 50 mg/ml; 3-methylpentacyclopentenone (called musk ketone) was used as a co-solvent with polyethylene oxide lauryl ether to form a 20 mg/ml emulsion. LD_(50) was administrated sequentially in tail vein of mice. The LD_(50) of Beijing and Shanghai musk ketone was 172, 152 mg/kg, and the co-solvent was 2500 mg/kg. The simple chance unit was used for intraperitoneal administration. The LD_(50) for Beijing and Shanghai musk ketone was 270, 290 mg/kg, and the co-solvent was 3000 mg/kg.