亮菌甲素是从假密环菌(Armillariellatabescens)中分离得的一种新的香豆素类化合物,化学名为3-乙酰基-5-羟甲基-7-羟基香豆素,对急性胆道感染有较好的疗效,无明显副作用。本品在 pH7.3～7.5含甘油的注射液(见表1处方1)中不稳定,常温贮存很易分解变质。本文对影响亮菌甲素注射液稳定性的有关因素,如原料来源、稳定剂的选择、pH 值等因素采用正交设计,按加速试验法进行优选。经试验表明,pH 值及稳定剂(硫脲)的加入为影响本品稳 Strychnine is a new coumarin isolated from Armillariellatacecens and has the chemical name 3-acetyl-5-hydroxymethyl-7-hydroxycoumarin Biliary tract infection has a good effect, no obvious side effects. This product is pH7.3 ~ 7.5 glycerol injection (see Table 1, prescription 1) is not stable, storage at room temperature is very easy to decompose and degenerate. In this paper, the factors that affect the stability of strychnine injection, such as the source of raw materials, the choice of stabilizer, pH and other factors using orthogonal design, according to the accelerated test method is preferred. The test shows that the pH value and stabilizer (thiourea) to affect the stability of this product