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应用ＳＩＶｍａｃ毒株感染中国恒河猴１３只，感染剂量为病毒液的１０－１～２×１０－５；感染食蟹猴４只，感染剂量为１０－２。感染后２周出现各种症状和体征如皮疹，浅表淋巴结肿大，脾肿大，血象白细胞总数下降，出现异常淋巴细胞和中性白细胞。感染后期Ｔ４下降，Ｔ４、Ｔ８比例倒置等。从外周血淋巴细胞和血浆分离病毒阳性，血清抗体上升。淋巴结组织切片呈规律性改变，即淋巴滤泡增生－滤泡耗竭－淋巴组织耗竭或逐渐恢复。感染后２．５个月有急性死亡病例，以后呈散在死亡例，尸检还发现机遇性感染如肺寄生虫，肺、肝巨细胞病毒感染等。
Thirteen Chinese rhesus monkeys were infected with SIVmac strain at a dose of 10-1 ~ 2 × 10-5 for the virus solution. Four cynomolgus monkeys were infected at a dose of 10-2. 2 weeks after infection, various symptoms and signs such as rash, superficial lymph nodes, splenomegaly and total white blood cells decreased, and abnormal lymphocytes and neutrophils appeared. T4 decreased late T4 infection, T4, T8 ratio inversion. Viruses were isolated from peripheral blood lymphocytes and plasma, and serum antibodies increased. Lymph node tissue sections changed regularly, that is, lymphoid follicular hyperplasia - follicular depletion - lymphoid tissue depletion or gradual recovery. 2.5 months after infection with acute deaths, followed by casual death cases, autopsy also found opportunistic infections such as lung parasites, lung, liver cytomegalovirus infection.