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Fasudil hydrochloride系脑血管挛缩治疗药,为异喹啉磺酰胺衍生物。本品不降低细胞内钙浓度,可抑制细胞内钙依赖性血管收缩。动物实验发现,本品可扩张挛缩状态的脑底动脉,使低下状态的大脑皮质血流量增加,可称之为广义的细胞内钙抑制剂。以安慰剂为对照,通过双盲比较试验,应用本品对蛛网膜下腔出血术后的脑血管挛缩及其所伴随的脑虚血症状的有用性进行研究。131例给予本品每次2ml(含30mg);136例给予生理盐水每次2ml,均静滴14日,每日3次。与安慰剂组相比,本品组对脑血管摄影上的脑血管挛缩的发生,症状性脑血管挛缩的发生,脑血管挛缩所致CT上的
Fasudil hydrochloride cerebrovascular contracture therapeutic drugs, isoquinoline sulfonamide derivatives. This product does not reduce the intracellular calcium concentration, inhibit intracellular calcium-dependent vasoconstriction. Animal experiments found that this product can expand the contracture state of the cerebral arteries, so that lower cerebral cortex blood flow increased, can be called a broad range of intracellular calcium inhibitors. Placebo as a control, through double-blind comparative test, the application of this product on the cerebral vascular contracture after subarachnoid hemorrhage and the accompanying usefulness of brain hemoptysis symptoms. 131 cases given this product each 2ml (containing 30mg); 136 cases were given normal saline 2ml, intravenously 14 days, 3 times a day. Compared with the placebo group, the product group on cerebrovascular angiography cerebrovascular contracture, the occurrence of symptomatic cerebrovascular contractures, cerebrovascular contractures caused by CT