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目的 提高中晚期胰头癌的姑息性治疗效果。 方法 对26 例中晚期胰头癌患者施行了胆肠吻合术,手术中行直线加速器肿瘤区直接照射,同时手术中经胃十二指肠动脉置入埋入式化疗泵,手术后行肿瘤区灌注化疗。 结果 随访3 ~27 个月,全疗程结束后肿块均有不同程度缩小,疼痛缓解率为100 % 。6 个月生存率为100 % ,12 个月生存率939 % ,24 个月生存率20 % 。死亡的5例,平均生存期为178 个月。 结论 内引流并术中放疗和灌注化疗是延长中晚期胰头癌患者生命的有效方法。
Objective To improve the palliative treatment of advanced pancreatic cancer. Methods Twenty-six patients with advanced pancreatic head cancer underwent biliary-enteric anastomosis. In the operation, the linear accelerator was directly irradiated. At the same time, a transfusion pump was implanted through the gastroduodenal artery and the tumor was injected after operation. Chemotherapy. Results After 3 to 27 months of follow-up, all tumors were reduced to varying degrees after the end of the treatment. The pain relief rate was 100%. The 6-month survival rate was 100%, the 12-month survival rate was 93.9%, and the 24-month survival rate was 20%. Five patients died and the average survival period was 17 to 8 months. Conclusion Internal drainage and intraoperative radiotherapy and infusion chemotherapy are effective methods for prolonging the lives of patients with advanced pancreatic cancer.