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目的初步尝试建立室性早搏诱发心动过速性心肌病犬模型,并探讨频发室早对左心功能的影响。方法健康杂种犬随机分为假手术组、起搏组(n=8)。起搏组犬在开胸直视条件下,分别于右室心尖和右室流出道缝制起搏电极,连接脉冲发放器,调节起搏参数,建立室性早搏二联律模型。假手术组同样行开胸手术,但不给予起搏。术前及术后4周,所有犬行超声心动图检查。结果 4周后,起搏组1只犬死于感染;起搏组犬左室舒张末期内径(cm)较术前增大(3.35±0.27vs2.86±0.10,P<0.05),左室收缩末期内径(cm)也较术前增大(2.72±0.21vs 2.07±0.20,P<0.05),左室射血分数较术前减小[(43.66±3.88)%vs(67.57±4.49)%,P<0.05]。假手术组手术前后无明显改变。结论采用开胸右室程序起搏可初步建立室性早搏二联律犬模型,频发室性早搏可导致左心室扩大和左心功能减退。
Objective To establish an early model of ventricular premature beats induced canine cardiomyopathy in dogs and to explore the impact of frequent premature ventricular contractions on left ventricular function. Methods Healthy mongrel dogs were randomly divided into sham operation group and pacing group (n = 8). Pacing dogs in open-chest surgery conditions, right ventricular apical and right ventricular outflow tract sewn pacemaker electrodes, connect the pulse dispenser, adjust the pacing parameters, the establishment of premature ventricular bicarbonation model. Sham-operated group also underwent thoracotomy, but did not give pacing. Four weeks before and after surgery, all dogs underwent echocardiography. Results After 4 weeks, one dog died of infection in the pacing group. The diameter of the left ventricular end-diastolic dimension (cm) in the pacing group was significantly higher than that before the operation (3.35 ± 0.27 vs 2.86 ± 0.10, P <0.05) Compared with the preoperative, the diameter of the left ventricle (cm) increased (2.72 ± 0.21 vs 2.07 ± 0.20, P <0.05) and the left ventricular ejection fraction decreased (43.66 ± 3.88)% vs (67.57 ± 4.49)%, P <0.05]. Sham operation group before and after surgery no significant change. Conclusion Pacing of thoracic right ventricular procedure can initially set up a bilateral canine model of premature ventricular premature beats. Frequent ventricular premature beats can lead to left ventricular enlargement and left ventricular dysfunction.