论文部分内容阅读
目的评价长春祁健生物制品有限公司(简称长春祁健)生产的冻干水痘减毒活疫苗(freezed-dried varicella attenuated live vaccine,Var V,以下简称水痘疫苗)在浙江省大规模使用后的安全性。方法通过全国疑似预防接种异常反应(adverse events following immunization,AEFI)信息管理系统,收集浙江省2014~2015年报告的接种水痘疫苗后发生的AEFI个案信息,采用描述性流行病学方法进行分析。结果浙江省共收到369例AEFI报告,估算报告发生率为28.04/10万剂次,其中异常反应89例,估算发生率6.76/10万剂次,所有案例男女性别比1.11∶1,时间分布集中在5~8月份,不良反应中一般反应主要表现为发热、红肿、硬结等临床症状,异常反应中则以过敏性皮疹为主(68例,76.40%),60.70%发生在接种后当天,99.19%的病例均治愈或好转。结论水痘疫苗接种后不良反应以一般反应为主,异常反应发生率低,预后良好,显示长春祁健生产的水痘疫苗在浙江省具有较好的安全性。
Objective To evaluate the safety of varicella attenuated live vaccine (VarV) produced by Changchun Qijian Biological Products Co., Ltd. (Changchun Qijian) for large-scale use in Zhejiang Province Sex. Methods AEFI information management system was used to collect information on AEFI cases in Zhejiang province from 2014 to 2015 after vaccination with chickenpox vaccine and the descriptive epidemiological analysis was conducted. Results A total of 369 cases of AEFI were reported in Zhejiang Province. The estimated incidence was 28.04 / 100 000, of which 89 were abnormal and the estimated incidence was 6.76 / 100 000. All cases had a male / female ratio of 1.11: 1 Focus on the 5 to August, adverse reactions in the general reaction of the main manifestations of fever, redness, induration and other clinical symptoms, allergic reactions in an allergic rash (68 cases, 76.40%), 60.70% occurred on the day after inoculation, 99.19% of the cases were cured or improved. Conclusions The adverse reactions of chickenpox vaccination are mainly general ones with low incidence of abnormal reactions and good prognosis. It shows that the chickenpox vaccine produced by Changchun Qijian has good safety in Zhejiang Province.