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目的观察合理使用长效硝酸酯类药物对稳定性心绞痛患者心肌缺血影响。方法本研究将稳定性心绞痛患者随机分为对称性给药组和非对称性给药组,观察治疗前后心绞痛发作程度变化,同时观察心肌缺血总负荷(包括有症状和无症状心肌缺血)变化。结果心绞痛发作程度、心肌缺血总负荷时间,非对称给药组疗效明显好于对称给药组(P<0.01)。且非对称性给药剂量少于对称性给药剂量。结论非对称性给药,既解决硝酸酯类药物耐药问题,又减少硝酸酯类药物用量,是临床合理应用硝酸酯类治疗稳定性心绞痛方法。
Objective To observe the effects of long-acting nitrates on myocardial ischemia in patients with stable angina. Methods In this study, patients with stable angina pectoris were randomly divided into symmetrical administration group and asymmetric administration group, the changes of angina pectoris before and after treatment were observed, and the total load of myocardial ischemia (including symptomatic and asymptomatic myocardial ischemia) Variety. Results The extent of angina pectoris and total myocardial ischemic load time were significantly better in the asymmetric group than those in the symmetrical group (P <0.01). And the asymmetric dose is less than the symmetrical dose. Conclusion Asymmetric drug delivery can not only solve the problem of drug resistance of nitrates, but also reduce the dosage of nitrates, which is a clinically appropriate method for the treatment of stable angina with nitrates.