Objective: To assess the effectiveness at the 6- month follow-up of an age-related macular degeneration (AMD) self-management program consisting of health education and enhancement of problem-solving skills in improving quality of life as shown by measures of mood and function. Methods: Six-month follow- up data were analyzed from 214 of 252 older adult volunteers (mean age, 80.8 years) with advanced AMD who had been randomly assigned to a 12- hour self-management program (n=82), a series of 12 hours of tape-recorded health lectures (n=66), or a waiting list (n=66). The primary outcome measure was emotional distress (Profile of Mood States). Secondary outcome measures included function (National Eye Institute Visual Function Questionnaire), self-confidence to handle AMD-specific challenges in daily life (AMD Self-ef ficacy Questionnaire), and depression status on the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Results: At the 6- month follow-up, participants in the self-managem-ent program reported significantly less emotional distress (P=.008), better function (P=.05), and increased self-efficacy (P=.006) compared with control subjects. The latter effects were more pronounced in the depressed than in the nondepressed subjects. Finally, the incidence of clinical depression at the 6- month follow-up was significantly lower in the self-management group (P=.05) than in the control group. Conclusion: The sustained positive effects at the 6- month follow-up provide support for the effectiveness of the AMD self-management program in reducing distress and disability, improving self-efficacy, and preventing depression in poorly sighted elderly patients with AMD. Objective: To assess the effectiveness at the 6- month follow-up of an age-related macular degeneration (AMD) self-management program consisting of health education and enhancement of problem-solving skills in improving quality of life as shown by measures of mood and the function. Six-month follow-up data was analyzed from 214 of 252 older adult volunteers (mean age, 80.8 years) with advanced AMD who had been randomly assigned to a 12- , a series of 12 hours of tape-recorded health lectures (n = 66), or a waiting list (n = 66). The primary outcome measure was emotional distress (Profile of Mood States). Secondary measure measures included function Institute Visual Function Questionnaire, self-confidence to handle AMD-specific challenges in daily life (AMD Self-ef ficacy Questionnaire), and depression status on the Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition. Results: At the 6- month follow-up, participants in the self-managem ent program were significantly less emotional distress (P = .008), better function (P = .05), and increased self-efficacy Finally, the incidence of clinical depression at the 6- month follow-up was significantly lower in the self-management group (P = .05) than in the control group. Conclusion: The sustained positive effects at the 6- month follow-up provide support for the effectiveness of the AMD self-management program in reducing distress and disability, improving self-efficacy, and preventing depression in poorly sighted elderly patients with AMD.