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目的：了解中药葛根的酒精提取物葛根素治疗血液高粘滞综合征，改善微循环的药理机制。方法：以血液高粘滞综合症病人做为研究对象，随机分为葛根素治疗组，及用其他抗凝药物治疗的对照组，并以健康人群为正常空白对照，利用WTP－AII型可谓式体外血栓形成，血小板粘附两用仪及SDI—III型血液自动计时粘度计检测等手段，观察葛根素和其他抗凝药物对血小板活化等方面的抑制作用，结果：表明葛根素在降低血小板粘附率，聚集率，改善血栓前状态，降低血液粘度等显著优于对照组，且不具备单一性，符合在体外／或体内有抑制血小板活化，抑制血小板血栓，又不引起出血的特点，且副作用小，使用安全，药源广阔，结论：葛根素可以做为一种抗栓，改善微循环的首选药物投入临床应用。
OBJECTIVE: To understand the pharmacological mechanism of Puerarin, a traditional Chinese medicine Pueraria extract, for the treatment of hyperviscosity syndrome of blood and improvement of microcirculation. Methods: Patients with hyperviscosity syndrome of blood were randomly divided into puerarin-treated group and control group treated with other anticoagulant drugs. Normal healthy controls were used as blank control group. WTP-AII type In vitro thrombosis, platelet adhesion dual-use instrument and SDI-III blood automatic timing viscometer test and other means to observe the puerarin and other anticoagulants on platelet activation and other aspects of the inhibitory effect: the results show that puerarin in reducing platelet viscosity Annexion rate, aggregation rate, improve the prethrombotic state, lower blood viscosity was significantly better than the control group, and does not have a single, in vitro and / or in vivo inhibition of platelet activation, inhibition of platelet thrombosis, without causing bleeding and Side effects, safe use, broad source of drug, Conclusion: puerarin can be used as an antithrombotic, microcirculation to improve the drug of choice for clinical applications.