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目的:筛选白刺花的药效部位。方法:根据白刺花所含成分的极性不同,对其分离出乙醇总提物、石油醚(Pet)、醋酸乙酯(EtOAc)、正丁醇(BuOH)及水溶性等不同成分。根据其主要临床应用,选择抗炎、抗过敏药效指标进行筛选实验。结果:BuOH部分对二甲苯所致小鼠耳肿胀有显著抑制作用,能显著降低小鼠腹部皮肤毛细血管通透性,对DNCB所致的DTH的影响有显著抑制作用,对右旋糖酐所致小鼠皮肤瘙痒的瘙痒次数有显著减少和显著缩短瘙痒时间的作用。EtOAc部分对右旋糖酐所致小鼠皮肤瘙痒的瘙痒次数有显著影响。结论:BuOH部分、EtOAc部分是白刺花的有效部位群,可对该两部分作进一步的分离和有效部位群的筛选。
Objective: To screen the medicinal sites of Nitraria chinensis. Methods: According to the polarity of the components contained in Nitraria tangutorum, the total ethanol extract, petroleum ether (Pet), ethyl acetate (EtOAc), n-butanol (BuOH) and water-soluble components were separated. According to its main clinical application, anti-inflammatory and anti-allergy efficacy indicators were selected for screening experiments. RESULTS: The BuOH fraction significantly inhibited the ear swelling of mice induced by xylene and significantly reduced the capillary permeability of the abdominal skin of mice. The effect of DOH on DTH caused by DNCB was significantly inhibited, and the mice induced by dextran were observed. There is a significant reduction in the number of itching pruritus and a significant reduction in itching time. The EtOAc fraction had a significant effect on the number of itching pruritus in mice caused by dextran. Conclusion: BuOH part and EtOAc part are the effective parts of Nitraria tangutorum, and the two parts can be further separated and the effective site group can be screened.