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胰岛素作用机制的研究可能仅与动物胰腺糖尿病时基本物质代谢破坏的机制之阐明相关。在近年来,我们和其它研究者的材料确定:当胰岛素装置功能低下时(四氧嘧啶糖尿病),动物的三羧循环代谢经常障碍:柠檬酸的转化阻滞、组织三羧循环中间产物浓度降低、乙酸盐的转化抑制,出现酮病等。注入三羧循环中间产物或胰岛素实际上对代谢给予同样的影响;缓和或完全解除了在糖尿病时观察到的代谢障碍;使家兎酸盐转化正常,使酮病、高血糖、糖尿等均消除了。由于糖尿病的发生是决定于三羧循环的障碍,对后者的影响,可能是部分甚至完全排除
The mechanism of insulin action may be related only to elucidation of the mechanism of the destruction of the essential substance metabolism in animal pancreatic diabetes. In recent years, we and other investigators have identified materials that are often obstructed by tricarboxylic circulatory metabolism in animals when impaired insulin device function (alloxan diabetes): blockade of citric acid conversion and reduction of triclosan intermediate product concentrations , Acetate conversion inhibition, ketosis and so on. Injecting the tricarboxylic recycling intermediate or insulin actually gives the same effect on metabolism; alleviates or completely eliminates the metabolic disorder observed in diabetes; normalizes the house acid salt and eliminates ketosis, hyperglycemia, diabetes and the like It’s Because the occurrence of diabetes is determined by the barrier of the three carboxylic acid cycle, the impact on the latter may be partially or even completely ruled out