论文部分内容阅读
本文报告了蝎毒素-Ⅲ的镇痛作用及其作用机制。蝎毒素-Ⅲ(ti?yusioxin-Ⅲ)是一种镇痛活性多肽。它是从东亚钳蝎毒中经过Cm-sephaden G-50柱层析提取,再用Sephaden G50凝胶过滤纯化而成。小鼠扭体实验表明TT-Ⅲ的镇痛作用较粗毒强三倍,较安痛定作用亦强。小鼠光热甩尾法实验结果TT-Ⅲ(0.424mg/kg iv)使痛阈(甩尾反应时间)提高4倍。侧脑室注射TT-Ⅲ14μg/kg抑制皮层诱发电位N波82±12%,与等剂量吗啡相似。利血平化大鼠,TT-Ⅲ对皮层诱发电位N波失去抑制作用,Ⅲ由侧脑室注入5HT后,TT-Ⅲ对N波的抑制率恢复到68.9%。
This article reports the analgesic effect of scorpion toxin-III and its mechanism of action. Trichotoxin-III (ti?yusioxin-III) is an analgesic active polypeptide. It was extracted from C. sinensis through Cm-sephaden G-50 column chromatography and purified by Sephaden G50 gel filtration. The writhing experiment in mice showed that TT-III had an analgesic effect three times more potent than crude drug and was more effective than Antongding. The results of the mice’s photothermal tail-flicking test TT-III (0.424 mg/kg iv) increased the pain threshold (flick tailing reaction time) by 4 times. Intracerebroventricular administration of TT-III at 14 μg/kg inhibited cortical evoked potential N-wave 82 ± 12%, similar to that of equal doses of morphine. In reserpinized rats, TT-III lost the inhibitory effect on the N-wave of cortical evoked potentials. After injecting 5HT into the lateral ventricle, the inhibitory rate of TT-III on N-waves returned to 68.9%.