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GABA摄取是控制神经突触间隙GABA浓度的重要功能。七十年代初期,Beart等以及Harris等分别从构效关系和临床药理学角度考虑,利用Iversen等的方法测试了一些GABA类似物和几十种中枢性作用药物对大鼠大脑皮层薄切片体外摄取~3H-GABA的影响,总结了一些规律。本文用大鼠脑匀浆摄取[~3H]-GABA的定量分析法测定了七种中枢性作用药物对GABA摄取的影响,以便进一步探讨某些作用比较明显、副作用较小的可逆性胆碱酯酶抑制剂、解胆碱能药物、长效安定类药物的有关作用机理。
GABA uptake is an important function of GABA concentration in the synaptic cleft. In the early seventies, Beart et al., And Harris et al. Respectively used the methods of Iversen et al. To test the in vitro uptake of thin sections of rat cerebral cortex using GABA analogs and dozens of central acting drugs from the perspective of structure-activity relationship and clinical pharmacology. ~ 3H-GABA, summed up some of the laws. In this study, the quantitative uptake of [~ 3H] -GABA in rat brain homogenate was used to determine the effects of seven central drugs on uptake of GABA in order to further explore some of the reversible cholinesters Enzyme inhibitor, cholinergic drugs, long-acting stability drugs related mechanism of action.