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In 1983,Cooper successfully performed the first case of right lung transplantation for a patient with end stage pulmonary fibrosis and long survival was achieved,which confirmed that lung transplantation is feasible clinically.The efficient lung transplantation has become the only hope for patients with end stage lung disease since.It′s crucial for the success of lung transplantation that the harvest and protection of the donor′s lung prior to transplantation.The preservation of donor′s lung is key for the function after lung transplantation.Apart from hypothermic approach,the perfusion procedure and the perfusion solution itself are also very important.The aim of this study was to establish an animal model,which could identify the effectiveness of preservation solution that could minimize the disturbance of the non-experimental factors so as to find the better preservation solution for lung protection.
In 1983, Cooper successfully performed the first case of right lung transplantation for a patient with end stage pulmonary fibrosis and long survival was achieved, which confirmed that lung transplantation is feasible clinically. The efficient lung transplantation has become the only hope for patients with end stage lung disease since .It’s crucial for the success ofIndigenic transplantation of the harvest and protection of the donor’s lung prior to transplantation. preservation of the donor’s lung is key for the function after lung transplantation. Part from hypothermic approach, the perfusion procedure and the perfusion solution itself are also very very. The aim of this study was to establish an animal model, which could identify the effectiveness of preservation solution that could minimize the disturbance of the non-experimental factors so as to find the better preservation solution for lung protection.