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Objective: To investigate the variations of contingent negative variations (CNV) , P300 and mismatch negativity ( MMN) in patients with obsessive compulsive disorder ( OCD) , depression and anxiety. Methods: Event - related potentials CNV, P300 and MMN were recorded in 31 patients with OCD by Nicolet Spirit Instrument, and were compared with that of 20 depression controls (DC) and 17 anxiety controls (AC) and 28 normal controls (NC) . Results: A significant difference of CNV among 4 subject groups was found in both post - imperative negative variation (PINV) and amplitudes (M1) (P < 0.01) (emergence of PINV were 45% , 60% , 35% , and 4% in OCD, DC, AC and NC groups respectively) . Compared with NC group, DC and AC groups showed decreased Ml amplitude ( P < 0.01) . A significant difference of P300 among 4 groups was found in both latencies (Cz/N2) and P3 and nontarget - P2 amplitudes (P<0.05-0.01). The delayed MMN latencies of OCD and DC were similar to that of P300 changes. Conclusions: CNV, P300 and MM
Objective: To investigate the variations of contingent negative variations (CNV), P300 and mismatch negativity (MMN) in patients with obsessive compulsive disorder (OCD), depression and anxiety. Methods: Event - related potentials CNV, P300 and MMN were recorded in 31 patients with OCD by Nicolet Spirit Instrument, and were compared with that of 20 depression controls (DC) and 17 anxiety controls (AC) and 28 normal controls (NC). Results: A significant difference of CNV among 4 subject groups was found in both Presence of PINV were 45%, 60%, 35%, and 4% in OCD, DC, AC and NC groups respectively. Compared with NC (P <0.01) group, DC and AC groups showed decreased M1 amplitude (P <0.01). A significant difference of P300 among 4 groups was found in both latencies (Cz / N2) and P3 and nontarget - P2 amplitudes (P <0.05-0.01) delayed MMN latencies of OCD and DC were similar to that of P300 changes. Conclusions : CNV, P300 and MM