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目的探讨阿托伐他汀强化降脂治疗和左旋氨氯地平联用对高血压患者血压的影响。方法选择2009年1月2010年11月住院及门诊原发性高血压合并高脂血症患者196例,均给予左旋氨氯地平和阿托伐他汀治疗8周后,复查血脂,从其中选择血脂正常者120例,随机分为对照组(单用左旋氨氯地平组)和治疗组(继续左旋氨氯地平联用阿托伐他汀),继续治疗20周后的血压情况。结果两组治疗20周后,治疗组收缩压和舒张压均较对照组下降明显,组间差异有统计学意义(P<0.01),治疗组优于对照组。结论高血压合并高脂血症患者,使用左旋氨氯地平降压和阿托伐他汀降脂治疗时,在血脂降至正常后,继续同时左旋氨氯地平降压和阿托伐他汀强化降脂治疗,降压效果优于单用左旋氨氯地平。
Objective To investigate the effects of atorvastatin combined with lipid-lowering therapy and levamlodipine on blood pressure in patients with essential hypertension. Methods A total of 196 inpatients and outpatients with essential hypertension complicated with hyperlipidemia were selected from January 2009 to November 2010. All patients were given levamlodipine and atorvastatin for 8 weeks. Blood lipids were examined and lipids were selected Normal 120 cases were randomly divided into control group (single use of L-amlodipine group) and treatment group (continue L-amlodipine combined with atorvastatin), continue treatment for 20 weeks after the blood pressure. Results After 20 weeks of treatment, the systolic and diastolic blood pressure of the treatment group decreased significantly compared with that of the control group, with significant difference between the two groups (P <0.01). The treatment group was superior to the control group. Conclusions In patients with hypertension and hyperlipidemia, when using L-amlodipine and atorvastatin to reduce lipid levels, after the blood lipids were reduced to normal, we continued the combination of antihypertensive effect of L-amlodipine and atorvastatin Treatment, antihypertensive effect is better than single levamlodipine.