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目的 探讨平阳霉素碘油乳剂 (PLE)对正常兔耳动脉是否具有祛血管作用及PLE作为一种栓塞剂的可能性。材料与方法 19只新西兰大白兔双侧耳廓后动脉 (PAA)分别灌注PLE(右耳为实验组 )和泛影葡胺碘油乳剂MDLE(左耳为对照组 ) ,观察不同时期兔双耳大体及耳廓后动脉组织学变化 ,比较两组血管组织学变化的差异性。结果 ( 1)实验组兔耳轮廓呈缺血性梗死表现。1～ 3天时水肿 ,4～ 7天水肿加重 ,8～ 14天耳廓下缘部分坏死脱落 ,15～ 2 8天脱落缘愈合。对照组 1～ 3天时亦水肿 ,4～ 7天水肿减轻 ,8天后恢复正常。( 2 )实验组耳廓后动脉光镜下表现 :1～ 3天时血管内膜结构完整 ,仅肌层水肿 ;4～ 7天内膜部分脱落 ,水肿加重 ;8～ 14天血管内血栓形成 ,15～ 90天血管部分再通。对照组耳廓后动脉 1～ 3天时改变与实验组相同 ,4～ 7天肌层水肿减轻 ,8～14天恢复正常。观察期内耳廓后动脉组织学变化两组间有明显差异 (P <0 .0 5 )。结论 PLE对兔耳动脉具有祛血管作用 ,可作为一种动脉栓塞剂 ,其栓塞作用较缓慢呈渐进性
Objective To investigate the effect of Pingyangmycin lipiodol emulsion (PLE) on the removal of blood vessels in the normal rabbit ear artery and PLE as an embolic agent. MATERIALS AND METHODS Twenty-nine New Zealand white rabbits were infused with PLE (right ear as experimental group) and MDLE (left ear as control group) Histopathology and posterior auricular artery histological changes, vascular changes in the two groups compared the differences. Results (1) The rabbit ear contour in experimental group showed ischemic infarction. 1 to 3 days when the edema, 4 to 7 days increased edema, 8 to 14 days, part of the bottom edge of the ear necrosis, 15 to 28 days off the edge healing. Control group also edema 1 to 3 days, 4 to 7 days edema reduced, returned to normal after 8 days. (2) In the experimental group, the auricle posterior arteries under light microscopy showed that the intima was intact with only edema of the muscular layer within 1 to 3 days; the part of the membrane was exfoliated and the edema was aggravated within 4 to 7 days; the intravascular thrombus was formed within 8 to 14 days, 15 to 90 days vascular recanalization. In the control group, the auricle posterior arteries changed from 1 to 3 days and the same as the experimental group. The muscle edema in 4 to 7 days was relieved and returned to normal in 8 to 14 days. During the observation period, there was a significant difference between the two groups (P <0.05). Conclusions PLE has the effect of removing blood vessels in the rabbit ear artery and can be used as an arterial embolization agent. The embolization effect is gradual