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对１２９例正常健康成人肥胖程度对左室舒张功能的影响及特点进行研究．以多普勒超声心动图检测的左室舒张功能指标为应变量，以可能对其有影响的生理因素为自变量，进行多元逐步回归，筛选出对其有显著相关关系的独立影响因素，着重分析肥胖对左室充盈的影响及特点．结果：反映总体肥胖程度的指标，体重指数为左室舒张期充盈多项指标的独立影响因素，其与二尖瓣Ｅ／Ａ流速比值和Ｅ峰充盈分数呈负相关，而与Ａ峰流速，Ａ峰面积，Ａ峰充盈分数成正相关．结果表明：伴随肥胖程度的增长，左室舒张功能显现出以舒张晚期流速及流速时间积分增大为主的充盈受损，其特点是同时存在左室泵功能增强的倾向．这种影响对超重者减肥以改善心功能状态，以及在某些心血管疾病的预防和治疗中，都是值得关注的问题．
The effects of obesity on left ventricular diastolic function in 129 normal healthy adults and their characteristics were studied. The indexes of left ventricular diastolic function measured by Doppler echocardiography were taken as the dependent variables. The influencing physiological factors were used as independent variables, and multiple stepwise regression was carried out to screen out the independent influencing factors with significant correlation between them Analysis of the impact of obesity on left ventricular filling and characteristics. Results: The index of overall obesity, body mass index were independent influencing factors of left ventricular diastolic filling, negatively correlated with mitral E / A ratio and E peak filling fraction, A peak area, A peak filling fraction was positively correlated. The results showed that with the increase of obesity, diastolic left ventricular diastolic function appeared to be impaired mainly by late diastolic flow velocity and temporal integral increase of flow velocity, which was characterized by the simultaneous increase of left ventricular pump function. This effect on weight loss in overweight to improve cardiac function, and in the prevention and treatment of certain cardiovascular diseases, are of concern.