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目的:观察高频振荡通气联合米力农对新生儿持续性肺动脉高压(PPHN)的效果。方法:选择郑州市第一人民医院新生儿科2013年8月~2014年5月收治的PPHN新生儿48例作为研究对象,随机分为两组,每组24例。观察组采取高频振荡通气联合米力农治疗,对照组采取常频机械通气联合米力农治疗,比较两组患者的疗效。结果:观察组总有效率为91.67%(22例),显著高于对照组(15例,62.50%)(P<0.05)。观察组治疗后12、24、48和96 h Pa O2/Fi O2分别为(79.83±10.51)、(112.53±15.66)、(153.57±21.17)和(225.71±26.45),均高于对照组,差异均有统计学意义(P<0.05)。观察组治疗后12、24、48和96 h肺动脉压水平均低于对照组(P<0.05)。结论:高频振荡通气联合米力农治疗新生儿PPHN效果较佳,可有效缓解肺动脉高压,具有重要的临床价值。
Objective: To observe the effect of high-frequency oscillatory ventilation combined with milrinone on persistent pulmonary hypertension (PPHN) in neonates. Methods: Forty-eight neonates with PPHN admitted to Department of Neonatology, First People’s Hospital of Zhengzhou from August 2013 to May 2014 were randomly divided into two groups (24 in each group). The observation group was treated with high-frequency oscillatory ventilation combined with Milrinone, the control group was treated with Frequent-Frequency Mechanical Ventilation plus Milrinone, and the curative effect was compared between the two groups. Results: The total effective rate in observation group was 91.67% (22 cases), which was significantly higher than that in control group (15 cases, 62.50%) (P <0.05). PaO2 / Fi O2 in the observation group at 12, 24, 48 and 96 h were (79.83 ± 10.51), (112.53 ± 15.66), (153.57 ± 21.17) and (225.71 ± 26.45), respectively, which were higher than those in the control group All were statistically significant (P <0.05). Pulmonary arterial pressure at 12, 24, 48 and 96 h after treatment in the observation group was lower than that in the control group (P <0.05). Conclusion: High-frequency oscillatory ventilation combined with Milrinone treatment of neonatal PPHN better, which can effectively relieve pulmonary hypertension, has important clinical value.