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目的探讨地塞米松对心肺复苏早期大鼠脑组织CD11b和ICAM-1含量的影响。方法采用夹闭气管法建立大鼠心肺复苏模型。将30只SD大鼠随机分为假手术对照组、心肺脑复苏(CPR)组、地塞米松(DXM)组,每组各10只大鼠。于自主呼吸循环恢复后2h检测大鼠脑组织CD11b及ICAM-1水平。结果①脑组织CD11b含量:CPR组为(620.488±38.723)ng/mg,较对照组(453.189±121.403)ng/mg明显增高(P<0.01);地塞米松组(770.060±156.847)ng/mg,较CPR组(620.488±38.723)ng/mg显著增加(P<0.01)。②脑组织ICAM-1含量:CPR组为(207.448±37.279)ng/mg,较对照组(113.447±31.116)ng/mg明显增高(P<0.05);地塞米松组(283.838±96.326)ng/mg,较CPR组显著增加(P<0.05)。结论CPR早期大鼠脑组织CD11b及ICAM-1水平显著增加;应用地塞米松进一步增高脑组织CD11b及ICAM-1水平。
Objective To investigate the effect of dexamethasone on the levels of CD11b and ICAM-1 in the brain tissue of rats during early cardiopulmonary resuscitation (CPR). Methods The model of cardiopulmonary resuscitation was established by clipping the trachea. Thirty SD rats were randomly divided into sham-operation control group, cardiopulmonary resuscitation (CPR) group and dexamethasone (DXM) group, 10 rats in each group. The levels of CD11b and ICAM-1 in rat brain tissue were measured 2h after resumption of spontaneous breathing cycle. Results ① The level of CD11b in brain tissue was significantly higher in CPR group than that in control group (453.189 ± 121.403) ng / mg (620.488 ± 38.723) ng / mg and 770.060 ± 156.847 ng / mg , Which was significantly higher than that of CPR group (620.488 ± 38.723) ng / mg (P <0.01). The level of ICAM-1 in brain tissue was significantly higher in CPR group than that in control group (207.448 ± 37.279 ng / mg, 113.447 ± 31.116 ng / mg, P <0.05), dexamethasone group (283.838 ± 96.326) ng / mg, which was significantly higher than that of CPR group (P <0.05). Conclusion The levels of CD11b and ICAM-1 in brain tissue of early CPR rats were significantly increased. Dexamethasone was used to further increase the levels of CD11b and ICAM-1 in brain tissue.