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目的探讨诱导痰细胞因子白细胞介素-17(IL-17)、IL-13、细胞间黏附分子-1(ICAM-1)、血管内皮生长因子(VEGF)在慢阻肺(COPD)、支气管哮喘及慢阻肺合并支气管哮喘患者中的表达及其意义。方法选取2015年3月至2016年3月在我院呼吸内科接受治疗的慢阻肺患者(A组)、支气管哮喘患者(B组)、慢阻肺合并支气管哮喘患者(C组)各60例,分别测定三组诱导痰细胞因子IL-17、IL-13、ICAM-1、VEGF水平并进行比较分析。结果 B组患者的FEV1%、FVC%、PEF%测定值均显著的高于A组、C组,差异均具有统计学意义(P<0.05);A组和C组患者的FEV1%、FVC%、PEF%测定值差异不显著(P>0.05);B组患者痰诱导IL-13水平高于A组、C组(P<0.05);B组和C组的痰诱导IL-17、ICAM-1、VEGF水平高于A组(P<0.05);C组患者的痰诱导VEGF水平高于B组(P<0.05)。结论慢阻肺、支气管哮喘及慢阻肺合并支气管哮喘患者的诱导痰细胞因子IL-17、IL-13、ICAM-1、VEGF表达水平不同,对于临床诊治具有一定的价值。
Objective To investigate the effects of sputum cytokines interleukin-17 (IL-17), interleukin-13 (IL-13), intercellular adhesion molecule-1 (ICAM-1) and vascular endothelial growth factor (VEGF) And COPD patients with bronchial asthma and its significance. Methods A total of 60 patients with COPD (group A), patients with bronchial asthma (group B) and patients with COPD and group C (group C) were selected from March 2015 to March 2016 in our department of respiratory medicine. The levels of IL-17, IL-13, ICAM-1 and VEGF in induced sputum were measured and compared. Results The FEV1%, FVC% and PEF% of group B were significantly higher than those of group A and group C (P <0.05). The FEV1%, FVC% (P> 0.05). The level of IL-13 in sputum induced by sputum in group B was higher than that in group A and C (P <0.05). The levels of IL-17 and ICAM- 1, the level of VEGF was higher in group A than in group A (P <0.05). The level of VEGF in group C was higher than that in group B (P <0.05). Conclusion The expression levels of IL-17, IL-13, ICAM-1 and VEGF in sputum with COPD, bronchial asthma and COPD patients with bronchial asthma are different, which is of value for clinical diagnosis and treatment.