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本文观察β-胡萝卜素和盐藻提取物对减轻阿霉素(A D M)诱发小鼠心脏毒性的作用。结果为单用 ADM 和 ADM 注射前腹腔注射过β-胡萝卜素及溶剂小鼠的心脏湿重均比 ADM 注射前预先腹腔注射盐藻提取物小鼠的明显减轻(P<0.05)。12mg/kg 的 ADM 单次注射以及在注射 ADM前,经盐藻提取物和β-胡萝卜素预先处理小鼠的存活率,在第35天分别是40%、100%和63%。ADM 剂量改为15mg/kg,在 ADM 注射后14天,上述分组小鼠的存活率分别是0%、50%和12.5%。这些结果提示,盐藻提取物在对抗 ADM 诱发的致死性心脏毒性上,具有保护作用,而β-胡萝卜素则无。
This article was to observe the effects of β-carotene and D. salina extracts on reducing the cardiac toxicity of adriamycin (A D M)-induced mice. The results showed that the cardiac wet weights of mice injected intraperitoneally with β-carotene and solvent before injection of ADM and ADM were all significantly lower than those of intraperitoneal injection of Dunaliella extract before ADM injection (P<0.05). The survival rate of mice pre-treated with Dunaliella salina extract and β-carotene before single injection of ADM at 12 mg/kg and before ADM injection was 40%, 100%, and 63% on day 35, respectively. The dose of ADM was changed to 15 mg/kg, and the survival rate of the grouped mice was 0%, 50%, and 12.5%, respectively, 14 days after ADM injection. These results suggest that D. salina extracts protect against ADM-induced lethal cardiotoxicity, while beta-carotene does not.