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N-叔丁基苯基呋喃甲酰肼是具有良好生物活性的含呋喃环双酰肼类昆虫生长调节剂(IGRs)的重要中间体,可由酰氯与叔丁基肼发生亲核反应制得。通过反应条件探索,获得了同时制备N1-叔丁基苯基呋喃甲酰肼和N2-叔丁基苯基呋喃甲酰肼的合成方法,并用此法制备了10个未见报道的新化合物,其结构通过1HNMR、IR、MS及元素分析确证。本文还通过计算化学方法对其反应机理及在不同条件下所生成异构体的现象进行了初步探讨。
N-tert-Butylphenyl furoyl hydrazide is an important intermediate containing furan ring double hydrazide insects growth regulators (IGRs) with good biological activity, which can be obtained by nucleophilic reaction between acid chloride and t-butyl hydrazine. Through the investigation of the reaction conditions, the synthesis of N1-tert-butylphenyl furoyl hydrazide and N2-tert-butylphenyl furohydrazide was obtained, and 10 new compounds were reported. Its structure was confirmed by 1HNMR, IR, MS and elemental analysis. In this paper, the reaction mechanism and the phenomenon of isomers formed under different conditions were also discussed through computational chemistry.