应用同位素技术，检测了部分晚期血吸虫病脾切除患者（切脾组）、巨脾型患者（巨脾组）以及正常对照人群（对照组）外周血嗜中性白细胞（ＰＭＮ）吞噬、杀菌功能以及血清调理作用，结果表明切脾组、巨脾组上述免疫指标显著低于对照组，切脾组与巨脾组相比较，ＰＭＮ吞噬、杀菌功能及血清调理作用差异无显著性。提示：晚期血吸虫病患者的ＰＭＮ吞噬功能低下，巨脾切除后未使之进一步恶化。 The phagocytosis and bactericidal activity of peripheral blood neutrophil (PMN) in some patients with splenic schistosomiasis (splenectomy group), splenomegaly group (splenomegaly group) and normal control group (control group) were detected by isotope technique Serum conditioning effect, the results show that the spleen group, giant spleen group of immune indicators was significantly lower than the control group, spleen group compared with the spleen group, PMN phagocytosis, bactericidal function and serum conditioning effect no significant difference. Tip: PMN phagocytosis in patients with advanced schistosomiasis dysfunction, splenomegaly did not make it further worsened.