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纤溶酶原激活物（Plasminogen activator,PA）是纤维蛋白溶解系统的重要组成成分。传统上认为:纤维蛋白溶解作用主要是机体消除血管内血栓（全身性纤维蛋白溶解作用）和血管外纤维性渗出物（局部纤维蛋白溶解作用）。近年来研究表明,纤维蛋白溶解系统涉及细胞外基质（ECM）的降解活动。细胞-ECM相互作用影响着细胞增殖、分化、粘连和迁移。脑PA的蛋白水解作用涉及神经细胞、神经胶质细胞迁移及轴突的生长;在病理学方面,有关PA与脑肿瘤、炎性疾病如多发性硬化症、病毒性脑炎、神经脱髓鞘等研究亦有重大进展,这无疑能帮助我们深入观察中枢神经系统某些疾病发病机制。
Plasminogen activator (PA) is an important component of fibrinolytic system. Traditionally, fibrinolysis is primarily the result of the body’s elimination of intravascular thrombi (systemic fibrinolysis) and extravascular fibroblast exudates (local fibrinolysis). Recent studies have shown that fibrinolytic systems involve the degradation of extracellular matrix (ECM). Cell-ECM interactions affect cell proliferation, differentiation, adhesion and migration. The proteolytic action of brain PA involves the migration of nerve cells, glial cells and the growth of axons. In terms of pathology, PA and brain tumors, inflammatory diseases such as multiple sclerosis, viral encephalitis, demyelination Other research has also made significant progress, which will undoubtedly help us to deeply observe the pathogenesis of certain diseases in the central nervous system.