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目的:探索米非司酮合并米索前列腺醇(米索)催经止孕的最佳剂量。方法:本文回顾性分析我院1995年3月至1997年12月在预期月经来潮日及延期1～5天自愿口服米非司酮及米索168例病人,采用双盲法,分组口服150mg米非司酮、口服 125mg米非司酮与口服100mg米非司酮合并等量米索,进行多方面的临床比较。结果:口服米非司酮100mg与125mg、150mg之间有显著差异,后二者之间无显著差异。分次口服米非司酮125 mg合并序贯口服米索0.6催经止孕的有效率98.28％。结论:米非司酮100mg与125mg、150 mg之间存在量效差异。分次口服米非司酮125mg合并序贯口服米索0.6mg,能有效地催经止孕。
Objective: To explore the optimal dose of mifepristone combined with misoprostol (misoprostol) in the process of stopping pregnancy. Methods: This retrospective analysis of our hospital from March 1995 to December 1997 in the expected menstrual cramps and postponed 1 to 5 days of spontaneous oral mifepristone and misoprostol 168 cases, double-blind method, group oral 150mg Pifepristone, oral 125mg mifepristone and oral administration of mifepristone equal amount of misoprostol, for many aspects of clinical comparison. Results: oral mifepristone 100mg and 125mg, 150mg significant difference between the two no significant difference. Graded oral mifepristone 125 mg combined with sequential oral misoprostol 0.6 effective rate of 98.28%. Conclusion: There are dose-effect differences between mifepristone 100mg and 125mg, 150 mg. Graded oral mifepristone 125mg combined sequential oral administration of misoprostol 0.6mg, can effectively promote the only pregnancy.